Major Collision Investigation Unit detectives are investigating a fatal collision in Avondale Heights this afternoon.
Emergency services were called to the intersection of Wood Street and Military Road following reports of a collision between a car and motorbike about 3.50pm.
A 25-year-old Beveridge woman who was a pillion passenger on the bike died at the scene.
The rider, a 24-year-old Heidelberg Heights man, was taken to hospital where he remains in a life-threatening condition.
The driver of the car, a 70-year-old Maribyrnong man, stopped at the scene and was not physically injured.
He has been interviewed by detectives and was released pending further enquiries.
Investigators are appealing for anyone who witnessed the collision or with dash cam footage of either vehicle prior to the collision to contact Crime Stoppers on 1800 333 000 or submit a report online at www.crimestoppersvic.com.au