Homicide Squad detectives are investigating the circumstances surrounding the death of a man in Deer Park overnight.
The man was stabbed at a Leila Street address about 11.15pm on Sunday, 5 December.
Despite the best effort of emergency services, he was died at the scene.
Police have arrested two men in the vicinity of the address who are in custody, assisting investigators with their enquiries.
At this early stage in the investigation, detectives believe both parties are known to each other.
Any witnesses, anyone with CCTV/dash cam footage or anyone with information that could assist police is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report online at www.crimestoppersvic.com.au