Police responded to reports of a number of vehicles hooning along Burnside Road at Ormeau at about 1.15am this morning.
Upon arrival, police attempted to intercept one of the vehicles however it drove off at high speed.
Police lost sight of the vehicle and located it, and a second vehicle, a short time later, crashed into a creek bed.
Five people were removed from the vehicles.
One person was transported to Princess Alexandra Hospital in a serious condition and another four were transported to Gold Coast University Hospital for minor injuries.
Forensic Crash Unit are currently investigating with oversight from the Ethical Standards Command.