Fibre boost could combat ‘chemo brain’ drain

Using a supplement to increase fibre intake while undergoing chemotherapy can significantly reduce brain inflammation and associated health issues, according to new research by the University of Adelaide and SAHMRI.

Brain inflammation is a common side effect of ongoing chemotherapy and a catalyst for a range of debilitating physical and psychological symptoms for which there’s no solution.

“Using pre-clinical models, we found that fibre supplementation directly causes positive changes in the gut microbiome and has the potential to alleviate brain inflammation following chemotherapy,” said Dr Courtney Cross, who led the study which is now published in Brain, Behavior and Immunity.

“Our study showed fibre reduced inflammation in the brain region responsible for memory by as much as 50%.

“This is really exciting because fibre supplementation is such a simple intervention that can be implemented cheaply and easily.”

Dietary fibre affects the microbiome by increasing the number of good microbes that produce anti-inflammatory metabolites called short-chain fatty acids. These short-chain fatty acids can enter the bloodstream and decrease inflammation around the body, including the brain.

Brain inflammation has been linked to a litany of neuropsychological issues, including cognitive impairment, depression, anxiety and fear of cancer recurrence, making it a target for researchers trying to reduce the non-physical side effects of cancer treatment.

“We’re all about improving the lives of people living with and beyond cancer any way we can, because in addition to receiving acute treatment, patients are also often on long term chemotherapy to prevent cancer recurrence and that significantly impacts their quality of life,” said the University of Adelaide’s Dr Cross.

“We’re optimistic that increasing fibre intake could have the potential to provide relief by improving the burden associated with all neuropsychological symptoms with one intervention.”

Researchers are now working towards starting clinical trials to prove whether upping dietary fibre has the same benefits on humans.

/University Release. View in full here.