Police are investigating the circumstances surrounding a fatal collision in Dimboola this afternoon.
It is understood two cars collided on the Western Highway about 5pm.
One of the drivers, who is yet to be formally identified, died at the scene.
The passenger was airlifted to hospital with non-life-threatening injuries.
The other driver was transported to hospital with non-life-threatening injuries.
The investigation into the collision remains ongoing.
Motorists are advised the Western Highway between Dimboola and Horsham will be closed for several hours.
Anyone who witnessed the collision or with dashcam is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report online at www.crimestoppersvic.com.au.