Senior researcher, Associate Professor Simon Phipps said the study’s finding was significant because it suggested diet affected the health of a mother’s breastmilk, which was key to triggering a baby’s immune resistance to sLRIs.
“Poor maternal diet increases the incidence of severe lower respiratory infections, such as pneumonia and bronchiolitis, in an infant. These infections are a major cause of infant morbidity worldwide, and increase childhood asthma risk,” said A/Prof Phipps.
“In preclinical models, we found that dietary fibre affects the composition of the mother’s milk microbiota, which in turn affects the development of the infant’s gut microbiota.
“When a breastfeeding mother eats a high-fibre diet, her healthy milk microbiota kicks off a process that promotes the development of an important population of immune cells. We have identified that the microbes talk to the cells that line the gut, and these cells then produce a growth factor that supports the immune cells in the bone marrow. These immune cells then protect the infant against severe lower respiratory infections.
“A low-fibre maternal diet disrupts this process of immune development.”
Associate Professor Simon Phipps
The study forms part of the ongoing effort by A/Prof Phipps’s laboratory to understand the mechanisms linking maternal diet, breastfeeding, and the microbiome to neonatal immune development and protection against acute and chronic diseases.
He said the findings suggest researchers may be able to prevent asthma if they can identify the healthy breastmilk microbes that trigger an infant’s immune resistance to sLRIs.
“Our data indicates that if we can promote a healthy gut in the very young, we will prevent asthma and various other chronic inflammatory diseases,” he said.
“However, the research still has a very long way to go. We are presently examining human milk to identify the microbes that confer protection against a severe lower respiratory infection and to confirm that the same molecular processes are involved.
“The end result could be a targeted probiotic, which may be provided to all infants, and in particular those who are being fed baby formula, to ensure optimal development of the infant’s immune system and to lower the incidence of various diseases.”
The study has been published in the journal Immunity (https://doi.org/10.1016/j.immuni.2023.03.002).
