Major Collision Investigation Unit detectives are investigating a fatal collision in West Melbourne this afternoon.
Emergency services were called to reports four vehicles had collided on Dynon Road just before 4.30pm.
A female child in one of the vehicles died at the scene.
The male driver of that vehicle as well as a second child were transported to hospital in a critical condition.
A further two passengers, a woman and child, were transported to hospital with non-life-threatening injuries.
The male driver and sole occupant of a second vehicle was transported to hospital with non-life-threatening injuries.
The female driver and sole occupant of a third vehicle sustained minor injuries and was treated at the scene by paramedics.
The male driver and sole occupant of a fourth vehicle was transported to hospital with non-life-threatening injuries.
The investigation into the circumstances surrounding the collision is ongoing.
Anyone who witnessed the collision, has CCTV or dashcam footage or anyone with information is urged to contact Crime Stoppers on 1800 333 000 or submit an online confidential report at www.crimestoppersvic.com.au.
