Florey researchers are recommending full-scale human trials after an insomnia drug helped a man withdraw from his 16 drinks-a-day addiction.
A Florey-led case report, published today in Clinical Case Reports describes how a 31-year-old man, who consumed 16 alcoholic drinks a day, had poor liver function and suffered from insomnia, withdrew from alcohol with the help of the insomnia drug suvorexant (Belsomra®).
The study was funded in part by the Victorian State Government’s Medical Research Acceleration Fund.
Minister for Education and Medical Research Hon Ben Carroll said the results demonstrate how Victoria’s world-leading medical research sector is improving people’s lives.
“We know addiction can have a detrimental impact on someone’s quality of life and mental health. That’s why the work of The Florey’s medical researchers is so important, helping to uncover new ways to treat alcohol use disorder.”
Minister for Mental Health Hon Ingrid Stitt said: “We know addiction remains a serious health issue across Victoria – that is why we are continuing to invest in research that helps us better understand how we can help people access the right support.”
Florey Professor Andrew Lawrence said the patient was treated at St Vincent’s Melbourne’s Drug and Alcohol withdrawal unit (under the care of Professor Yvonne Bonomo) for one week and continued the treatment at home for three months.
“After 13 weeks on suvorexant he’d had a complete turnaround. He had stopped drinking all together, his liver function had improved and he no longer had insomnia. This is a remarkable result.”
Professor Lawrence said insomnia features strongly in both withdrawal and relapse to alcohol consumption.
“Sleep-associated problems affect close to half of all people with alcohol use disorder. Yet sleep disruption is an often-overlooked symptom that can hamper recovery from alcohol use disorder.”
Professor Lawrence said suvorexant is a dual orexin receptor antagonist, which suppresses wakefulness by essentially blocking the brain’s orexin system.
“Although this case report is of just one person’s experience, we already have abundant evidence in preclinical animal models supporting a role for the orexin system in alcohol use disorder.”
Professor Lawrence said the patient’s experience suggests dual orexin receptor antagonists could be a new weapon to help treat alcohol use disorder.
“The next step should be to conduct larger human trials to test whether suvorexant helps a broader group of people who have both alcohol use disorder and insomnia.”
About us:
Funding
This work was supported by a Perpetual IMPACT philanthropic grant to Andrew Lawrence and Erin Campbell (Florey) via the Percy Baxter Charitable Trust and a Victoria Medical Research Acceleration Fund 2 grant from the Victorian State Government to Andrew Lawrence and Yvonne Bonomo. We acknowledge the Victorian State Government Operational Infrastructure Scheme.
About The Florey
The Florey is Australia’s leading brain research institute with a focus on improving the lives of people with neurological and psychiatric conditions. The Florey’s research missions are centred around dementia, epilepsy, mental health and developing ways to protect and repair the brain. These missions are strengthened by The Florey’s expertise in neurotherapeutics, neuroimaging, synaptic biology and systems neuroscience. With 600 researchers, The Florey is the largest research centre of its kind in the southern hemisphere.
