Detectives from the Major Collision Investigation Unit are investigating a two-car collision in Maribyrnong last night.
Emergency services were called after a white Toyota sedan collided with a BMW sedan on Birdwood Street, near the intersection of Merlyn Street, about 6.05pm.
A marked police vehicle observed the oncoming Toyota overtaking a tram on the wrong side of Gordon Street shortly before the collision.
The collision occurred before the police unit was able to attempt to intercept the Toyota.
The driver of the BMW, a 34-year-old Sunshine North woman was taken to hospital with non-life-threatening injuries. A 5-year-old girl, also in the same vehicle, was taken to hospital with potentially life-threatening injuries.
The driver of the Toyota, a 26-year-old Flemington man, was taken to hospital under police guard with serious injuries.
A 24-year-old Flemington man who was a passenger in the Toyota was also taken to hospital with serious injuries.
A third man from the Toyota fled the scene on foot and was believed to be carrying a knife.
He was last seen on Mitchell Street and is described as African in appearance, was wearing a red baseball cap and dark-coloured clothing.
Professional Standards Command will oversee the investigation, which is standard procedure, where police involvement precedes a serious collision.
Anyone who witnessed the crash, has dashcam footage or further information is urged to contact Crime Stoppers on 1800 333 000 or submit a report online at www.crimestoppersvic.com.au.
