Detectives are investigating a collision in Kaarimba this morning.
Emergency services were called to reports a Ford Ranger and Mazda had collided head-on on Barmah-Shepparton Road, near Purdies Road, about 7.20am.
The driver of the Mazda, a 39-year-old man, was airlifted to hospital with critical injuries.
The passenger, also a 39-year-old man, was airlifted to hospital with life-threatening injuries.
The driver of the Ford Ranger, a 31-year-old man, was transported to hospital under police guard with serious but non-life-threatening injuries.
Major Collision Investigation Unit detectives are enroute and will investigate the circumstances surrounding the collision.
Anyone who witnessed the incident, has dashcam or CCTV footage or anyone with information is urged to contact Crime Stoppers on 1800 333 000 or submit an online confidential report at ww.crimestoppersvic.com.au.
