Firefighters are battling a fire at an unused Motel in Bullarto, near Daylesford.
CFA was called to the fire around 10.40am, on arrival they found the Motel fully engulfed.
One gas cylinder on site released during the fire.
There are no reported injuries as a result of the fire.
Victoria Police will investigate alongside CFA as the cause has been deemed suspicious.
Nine CFA trucks are on scene.