Police are investigating a collision in Moolap this afternoon.
Emergency services were called to reports an e-bike and car had collided near the intersection of Portarlington and Whitehorse roads about 3.30pm.
The rider of the e-bike, a 17-year-old boy, was transported to hospital with non-life-threatening
The male teenage passenger, who is yet to be formally identified, was airlifted with life-threatening injuries.
The driver of the car was not injured and stopped at the scene.
Major Collision Investigation Unit detectives are enroute and will investigate the circumstances surrounding the collision.
Anyone who witnessed the incident, has dashcam or CCTV footage or anyone with information is urged to contact Crime Stoppers on 1800 333 000 or submit an online confidential report at ww.crimestoppersvic.com.au.